British Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack against an underground arms cache in Syria employed by the IS group, according to the UK Ministry of Defence.
The location, located using surveillance, was thought to be storing arms and explosives, the statement said, and was situated in mountains just above the ancient city of Palmyra in Syria's central region.
"Our fighter planes utilized precision-guided Paveway IV munitions to strike a number of entry passages leading to the site... early reports indicate the target was engaged successfully," the ministry announced.
There was no evidence of any civilian impact in the attack on Saturday evening and each participating jet returned to base without incident, the ministry further stated.
The Typhoon fighters were supported by a Voyager refuelling tanker.
IS - referred to as Daesh - imposed extremist governance over parts of Iraq and Syria before its territorial defeat in 2019.
"This strike demonstrates the UK's leading role, and commitment to work closely with our partners, to eradicate any resurgence of IS and their harmful and extremist ideologies in the area," UK Defence Secretary John Healey remarked.
RAF aircraft have carried out patrols over Syria to "prevent any attempted resurgence" of the group after its routing at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I must thank every member of our armed forces who took part in this operation for their professionalism and their courage," Healey added. "Including them were thousands of British troops stationed over the holidays. This mission, to take out militants who threaten our safety, shows how our armed forces are prepared to act, continuously, ensuring Britain's security at home and influential overseas."
In December, the United States armed forces executed what it termed a "major assault" on Daesh sites in the country, subsequent to an attack resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations says Daesh still maintains roughly 5-7 thousand militants in both countries.